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Iloperidone hydrochloride

CAS No. 1299470-39-5

Iloperidone hydrochloride ( HP-873 hydrochloride )

Catalog No. M11203 CAS No. 1299470-39-5

An atypical antipsychotic that exhibits high affinity to serotonin 5HT2A (Ki =5.6 nM), dopamine D2 (Ki=6.3 nM) and D3 (Ki=7.1 nM) and noradrenaline α1 receptors (Ki=0.36 nM).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Iloperidone hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    An atypical antipsychotic that exhibits high affinity to serotonin 5HT2A (Ki =5.6 nM), dopamine D2 (Ki=6.3 nM) and D3 (Ki=7.1 nM) and noradrenaline α1 receptors (Ki=0.36 nM).
  • Description
    An atypical antipsychotic that exhibits high affinity to serotonin 5HT2A (Ki =5.6 nM), dopamine D2 (Ki=6.3 nM) and D3 (Ki=7.1 nM) and noradrenaline α1 receptors (Ki=0.36 nM), moderate affinity for D4 (25 nM), 5HT6 (43 nM), 5HT7 (22 nM), and low affinity for 5HT1A (168 nM), D1 and histamine H1 receptors; is used for the treatment of schizophrenia.Schizophrenia Approved
  • Synonyms
    HP-873 hydrochloride
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    Neurological Disease
  • Indication
    Schizophrenia

Chemical Information

  • CAS Number
    1299470-39-5
  • Formula Weight
    462.94
  • Molecular Formula
    C24H28ClFN2O4
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC(C1=CC=C(OCCCN2CCC(C3=NOC4=CC(F)=CC=C34)CC2)C(OC)=C1)=O.[H]Cl
  • Chemical Name
    Ethanone, 1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]-, hydrochloride (1:1)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Barr AM, et al. Neuropharmacology. 2006 Sep;51(3):457-65.
2. Szewczak MR, et al. J Pharmacol Exp Ther. 1995 Sep;274(3):1404-13.
3. Sainati SM, et al. J Clin Pharmacol. 1995 Jul;35(7):713-20.
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